Nonshivering thermogenesis revisited: sympathetic and non-sympathetic contributions

Factors of diet and environment contribute to complementary, additive mechanisms that influence the magnitude induced thermogenesis generated in man animals. Both short terms sympathetically mediated longer acting thyroidal pathways have been identified appear function a metabolically coordinated fashion facilitate biochemical physiologic energy balance implicating multiple organs peripheral tissues during periods over- under-nutrition. In congenic lean rodent model known express parameters environmentally thermogenesis, sympathetic contributions each contributed approximately 50% relative increase VO2 quietly resting animals after consuming high palatable as determined presence vs. absence α-methylparatyrosine, sympathoplegic chemical agent. contrast, obese phenotype corpulent other strains, both adaptive thermogenic are impaired response nutritional environmental challenge, contributing greater efficiency metabolism body fat accretion. Thus, purpose present review is approximate qualitative distribution between two primary factors linked process resulting expression normally rat, LA/Ntul//-cp.